Mechanisms underlying treatment response in psychosis (MUTRIPS)
MUTRIPS is a European Research Council funded project which aims to identify the neural mechanisms underlying antipsychotic treatment response in psychosis. The key hypothesis is that lack of adequate response to treatment, the persistence of symptoms despite optimal contemporary treatment, is characterised by a failure of prefrontal cognitive control mechanisms, specifically in modulation of feedback learning.
We are utilising structural and functional magnetic resonance imaging (MRI) both in chronic schizophrenia and in first episode psychosis. Our measures include task-related MRI, magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), and multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT).
Researchers: Sukhi Shergill, Charlotte Horne, Tess Verneuil, Timea Szentgyorgyi, Imke Jansen
Collaborators: Kelly Diederen, Dan Joyce, Rosalyn Moran, Robert Leech, Lucy Vanes, Elias Mouchlianitis, Anne Fett, Abbie Barnes
Start date: March 2013
End date: November 2018